This open access book constitutes the refereed proceedings of the 15th International Conference on Semantic Systems, SEMANTiCS 2019, held in Karlsruhe, Germany, in September 2019. The 20 full papers and 8 short papers presented in this volume were carefully reviewed and selected from 88 submissions. They cover topics such as: web semantics and linked (open) data; machine learning and deep learning techniques; semantic information management and knowledge integration; terminology, thesaurus and ontology management; data mining and knowledge discovery; semantics in blockchain and distributed ledger technologies.