Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease
Sharon Moalem
Top 10 Best Quotes
“Why would you take a drug that is guaranteed to kill you in forty years? One reason, right? It's the only thing that will stop you dying tomorrow.”
“By the way, the next time you get your cholesterol checked, make a note of the season. Because sunlight converts cholesterol to vitamin D, cholesterol levels can be higher in winter months, when we continue to make and eat cholesterol but there’s less sunlight available to convert it.”
“There is one notable exception to Jablonski and Chaplin’s equation—and it’s the exception that proves the rule. The Inuit—the indigenous people of the subarctic—are dark-skinned, despite the limited sunlight of their home. If you think something fishy’s going on here, you’re right. But the reason they don’t need to evolve the lighter skin necessary to ensure sufficient vitamin D production is refreshingly simple. Their diet is full of fatty fish—which just happens to be one of the only foods in nature that is chock-full of vitamin D. They eat vitamin D for breakfast, lunch, and dinner, so they don’t need to make it. If you ever had a grandmother from the Old World try to force cod liver oil down your throat, she was onto something for the same reason—since it’s full of vitamin D, cod liver oil was one of the best ways to prevent rickets, especially before milk was routinely fortified with it. IF YOU’RE WONDERING how people who have dark skin make enough vitamin D despite the fact that their skin blocks all those ultraviolet rays, you’re asking the right questions. Remember, ultraviolet rays that penetrate the skin destroy folate—and ultraviolet rays that penetrate the skin are necessary to create vitamin D. Dark skin evolved to protect folate, but it didn’t evolve”
“far as to say that white-skinned people are actually black-skinned mutants who lost the ability to produce significant amounts of eumelanin. Redheads, with their characteristic milky white skin and freckles, may be a further mutation along the same lines. In order to survive in places with infrequent and weak sunlight, such as in parts of the U.K., they may have evolved in a way that almost completely knocked out their body’s ability to produce eumelanin, the brown or black pigment.”
“connection between skin color and sunlight. The results were as clear as the sky on a cloudless day—there was a near-constant correlation between skin color and sunlight exposure in populations that had remained in the same area for 500 years or more. They even produced an equation to express the relationship between a given population’s skin color and its annual exposure to ultraviolet rays. (If you’re feeling adventurous, the equation is W = 70-AUV/10. W represents relative whiteness and AUV represents annual ultraviolet exposure. The 70 is based on research that indicates that the whitest possible skin—the result of a population that received zero exposure to UV—would reflect about 70 percent of the light directed at it.)”
“Interestingly, it’s possible that practices related to the observance of Passover helped to protect Jewish neighborhoods from the plague. Passover is a week-long holiday commemorating Jews’ escape from slavery in Egypt. As part of its observance, Jews do not eat leavened bread and remove all traces of it from their homes. In many parts of the world, especially Europe, wheat, grain, and even legumes are also forbidden during Passover. Dr. Martin J. Blaser, a professor of internal medicine at New York University Medical Center, thinks this “spring cleaning” of grain stores may have helped to protect Jews from the plague, by decreasing their exposure to rats hunting for food—rats that carried the plague.”
“In evolutionary terms, that means we asked for it.”
“A Canadian physiologist named Norman Kasting discovered that bleeding animals induces the release of the hormone vasopressin; this reduces their fevers and spurs their immune system into higher gear. The connection isn’t unequivocally proven in humans, but there is much correlation between bloodletting and fever reduction in the historic record. Bleeding also may have helped to fight infection by reducing the amount of iron available to feed an invader, providing an assist to the body’s natural tendency to hide iron when it recognizes an infection.”
“the notion that T. gondii may trigger schizophrenia is supported by recent studies demonstrating that mice that have toxoplasmosis modify their behavior when given antipsychotic medication. Researchers at Johns Hopkins University are now testing whether schizophrenics might be helped with antibiotics that fight toxoplasmosis.”
“if there’s fire on the mountain or lightning and storm and a god speaks from the sky. That means someone is hearing the outcry and the birth-cry of new life at its term.”
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Book Keywords:
survival-of-the-sickest, evolution, science, genetics
